Abstract Form

Title: Intravitreal injection of expanile sulfur Hexafluoride and head maneuvering for the treatment of Vitreomacular traction
Author(s): Mehdi Modarreszadeh, Farzaneh Aghamohammadi, Sayyed Amirpooya Alemzadeh
Presentation Type: Oral
Subject: Retina and Retinal Cell Biology
Presenting Author:
Name: Mehdi Modarreszadeh
Affiliation :(optional) Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
E mail: mmodarres51@yahoo.com
Phone: 88074986
Mobile: 09121266221
Abstract (Max 200 words)
Purpose: To study the efficacy of a single intravitreal injection of expanile gas (SF6) in releasing vitreomacular traction.
Methods: Eighteen eyes of eighteen patients with symptomatic and persistent VMT (>3 months duration) on spectral-domain optical coherence tomography (SD OCT) received a single intravitreal injection of 0.3 cc ml of 100% SF6 patients were instructed for head maneuvering (drinking bird maneuver). Primary outcome measure was the number of eyes with complete VMT release on OCT, one week and one month following treatment. Secondary outcomes included changes in visual acuity (VA)and central foveal thickness (CFT) 1 Month following treatment.
Results: Mean age (±SD) was 64.47 ±9.14 years. In 11 patients (57.9%) VMT was released 1 week and in 14 patients (73.7%) 1 month after the intervention.ERM was present in 9 patients that VMT released in 6 (66.6%) of them. Ten patients had PDR ,that VMT released in 8 (80%) of them. Four patients who had stage II macular holes before injection progressed to stage III and IV macular hole. But one patient with lamellar hole before injection had improvement.Four of patients had diffused VMA (>1500 micron) and in 2 of them (50%) VMT didn’t release. Fourteen patients had focal VMA (≤1500 micron) and in 11 of them VMT released (p=0.219). Mean final VA increase 1.02 logMAR units from baseline (p=0.064). Mean CFT on SD OCT decrease by an average of 85.27 micron after injection (p=0.094).
Conclusion: Intravitreal SF6 injection and head maneuvering maybe offers a minimally invasive and low cost alternative to PPV in patients with symptomatic and persistent VMT. Further studies are warranted.