| Title:
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Correlation of Cystatin-c to Diabetic Retinopathy Severity and Acute Phase Reactants
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| Author(s):
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Joobin Khadamy1,2, Gholamhossein Yaghoobi2, Abbas Hosseini Rad2, Mahnaz Najafi2, Saeed Reza Heydari3
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| Presentation Type:
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Oral
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| Subject:
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Retina and Retinal Cell Biology
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| Others:
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Presenting Author:
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| Name:
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Joobin Khadamy
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| Affiliation :(optional)
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1. Department of Ophthalmology, Vali-e-Asr Hospital, Birjand University of Medical Science 2. Eye Research Center, Rassoul Akram hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran
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| E mail:
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joobin_kh@hotmail.com
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| Phone:
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Mobile: |
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Abstract (Max 200 words)
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| Purpose:
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To evaluate the Cystatin-c (Cys-c) levels correlation with diabetic retinopathy severity and acute phase reactant (erythrocyte sedimentation rate (ESR) and High-sensitivity C - reactive protein (hs-CRP)).
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| Methods:
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All diabetic patients who were referred for diabetic retinopathy (DR) screening in a month were enrolled. Demographic data were recorded. All patients has undergone full ophthalmic exam. At the same day, all patients were tested for Hemoglobin A1c (HbA1c), ESR, hs-CRP and Cys-c serum levels.
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| Results:
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Sixty seven diabetics (19 (28.3%) without retinopathy, 22 (32.8%) non-proliferative retinopathy and 26 (38.8%) proliferative retinopathy) were enrolled in the study. The mean age, sex distribution, mean duration of diabetes, prevalence of hypertension, dyslipidemia and smoking status and HbA1c levels were not significantly different between the three groups. The mean levels of Cys-c increases significantly as retinopathy progress (1.1±0.48, 1.22±0.38 and 1.71±0.92 (P=0.007), respectively). In multiple regression analysis, only the Cys-c could statistically significantly predict DR severity (p = 0.025).
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| Conclusion:
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This study showed Cys-c levels increase; as DR progress. The Cys-c predict DR severity independent of acute phase reactants. It could be used as a predictive marker by primary care physicians to distinguish patients at higher risk of sever DR. Larger randomized studies are warranted to confirm these findings. Reviewing physiological role of the Cys-c; we proposed that the Cys-c may be a protective response to catalytic stress, rather than being a pathogenic factor in microangiopathies.
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| Attachment:
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